Windows 10 64bit
Nvidia GeForce GTX 570
Game version: 1.4.3f1
Destroying Marcus's dungeon heart on mission 4 in the campaign does not seem to complete the relevant objective leading to the mission being impossible to complete. Destroying the inhibitor still works as expected.
The first two saves I pretty much cleaned the map before finishing the enemy keeper. Reading that it could be a problem with the siege shrines I skipped them all for the third/fourth save. Also skipped using the worker artifact as that has apparently caused problems before (although old reports, probably fixed).
The first two saves are two separate games saved after the mission should be over, unless I've done something wrong. The third save is half a minute before finishing Marcus and the fourth save is the same after the mission should be over.
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